Cayne is a transgender who became known in the New York City nightclub scene during the 1990s, where she served as a choreographer and drag performer.
Cayne became the first transgender actress to have a recurring role; playing Carmelita, a transgender in the primetime television series Dirty Sexy Money, which ran from 2007 and 2008. She has also been featured in numerous movies including Stonewall 1995), To Wong Foo Thanks for Everything! Julie Newmar (1995), Always Something Better (1996), Mob Queen (1998), Charlie! (1999), In the Closet (1999), My Heart Belongs to Data (2006), Starrbooty (2007), Libanese Loira (2008), Making The Boys (2011), Meth Head (2012), Groom’s Cake (2012), and Crazy Bitches (2014). Besides, Cayne has also starred in episodes of the TV series CSI: NY, Drop Dead Diva, Nip/Tuck, Necessary Roughness, New York Undercover, and Elementary.